Causative Factors for the Initiation of Atherosclerotic Plaques
Causative Factors for the Initiation of Atherosclerotic Plaques
Atherosclerosis: Open Access (Omics Publishing S.L) has announced almost 50 % discount on article processing charge to commemorate its 10th Anniversary.
Atherosclerosis: Open Access is an open access, peer-reviewed journal that focuses and welcomes submissions on all aspects of Coronary Heart disease, Stroke, Peripheral Arterial Disease, Chronic Kidney Disease, arteriosclerosis, Coronary Atherosclerosis, intracranial atherosclerosis etc.
It gives us great pleasure to announce the call for paper on the occasion of 10th Anniversary of the Journal at special and hefty discount of up to 50 % on one-time article processing charge. Prospective academicians and scientists are encouraged to utilize this opportunity to get their articles reviewed, processed and published at relatively faster pace and at lower charges. In addition to this, the authors who publish with us during the year-long celebrations will also be eligible for academic awards recommended by the editorial panel.
The Archive page contains wide variety of articles such as Research / Review / Case reports / short communication / Mini review / Prospective / Letter to Editors Etc. We would like introduce a Research article which has been spread to the widest audience of experts; and thus increased in readership, citations and altimetry score.
Title: “Causative Factors for the Initiation of Atherosclerotic Plaques”
Abstract: Three main factors account for the accumulation of lipoprotein complexes at focal zones of the arterial tree which then can lead to plaque development: (a) diverging flow of the arterial tree which is punctuated at arterial bifurcations, (b) the arterial wall is a semi-permeable membrane with steady bulk flow of fluid, through the interstices of the intimal wall, and (c) shear dependent diffusivity of macromolecules which depends strongly on local shear rate. In the absence of the any factors, either no wall accumulation would occur or lipoproteins would form layers over the entire arterial tree. Models are developed and applied to various zones of an arterial branch, which shows large variations in wall accumulations. The models show that the most important aspects occur from the wall. Very high accumulations of lipids of factors of 2 to 6 times the bulk values in the recirculating flow downstream of branches or at aneurisms while other are show minimal accumulations. These causative factors directly relate to clinical data, which links smoking to increased wall permeability and thus permeation rate, to incidence and severity of atherosclerotic plaques as well as substantial data linking high blood pressure affecting wall permeation rate with severity or incidence of plaque formation. There is also evidence of feedback whereby the local swelling of the intima increases the interstitial gaps which allow bulk fluid to pass more readily, thus accelerating the local accumulations in these zones. This work integrates aspects, which have been studied separately but are not all present in previous work.
To have a glance at the full length manuscript, you can visit us at our archive page and Currently, Journal’s Archive is holding not only normal issues but also focusing on special issues. The purpose of special issues is to publish the most exciting research with respect to the subjects of Atherosclerosis / Cardiovascular Diseases and to provide a rapid turn-around time regarding reviewing and publishing, and to publicize the articles freely for research, teaching and reference purposes. Submit manuscript of your research articles or special issue articles online through manuscript submission or forwarded to the Editorial Office at atherosclerosis@oajournal.org
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Atherosclerosis: Open Access