Microbiological and Physico-Chemical Stability of Ketamine Solution for Patient-Controlled Analgesia Systems


Microbiological and Physico-Chemical Stability of Ketamine Solution for Patient-Controlled Analgesia Systems

Research & Reviews: Journal of Hospital and Clinical Pharmacy (RROIJ Publishing) is an open access, peer-reviewed journal that focuses and welcomes submissions on all aspects of  not only Hospital and Clinical pharmacy but also in aspects like Drugs & Drug information studies, General anaesthesia, Automatized anaesthesia, Paediatric Anaesthesia, Obstetric Anaesthesia, Neuroanesthesia, All kind of surgeries General medicine & Critical care medicine, Preoperative Evaluation & Postoperative effects, Pain management, Drug information studies, Clinical reviews, Pharmacy practices, Patient care & Counselling, Ischemia reperfusion, Clinical trials, Patient management, Patient care, Nursing, Disease and hospitalization, Trauma care, and Incentive care etc.  

It gives us great pleasure to announce the call for paper on the occasion of 10th Anniversary of the Journal at special and hefty discount of up to 50% on one-time article processing charge. Prospective academicians and scientists are encouraged to utilize this opportunity to get their articles reviewed, processed and published at relatively faster pace and at lower charges. In addition to this, the authors who publish with us during the year-long celebrations will also be eligible for academic awards recommended by the editorial panel.

The Archive page contains wide variety of articles such as Research / Review / Case reports / short communication / Mini review / Prospective / Letter to Editors Etc. We would like introduce a Research article which has been spread to the widest audience of experts; and thus increased in readership, citations and altimetry score.

Title: “Microbiological and Physico-Chemical Stability of Ketamine Solution for Patient-Controlled Analgesia Systems

Abstract: Ketamine solution is regularly used along with opioids to treat patient suffering from refractory cancer pain. The aim of this study was to determine the expiry date of solutions of ketamine, by conducting microbiological and physicochemical stability assay. Five series of six ketamine solutions at 1 mg/mL in the portable PCA systems were stored at room temperature or at +33°C for respectively 28 days and 7 days. They were sampled immediately after preparation, and some day of the following weeks. According to European Pharmacopoeia VIIIth edition, microbiological stability was assessed by the research of antimicrobial activity of the product and sterility tests. The physico-chemical study was performed by determining aspect, pH, osmolality and loss of weight evolution. All samples were tested to follow variation of drug concentrations by high performance liquid chromatography coupled to an ultraviolet detector. A study of degradation forced was realized to separate degradation product. There were changes in pH and loss of weight values after 28 days. No precipitation or change in color was observed in any of the sample solutions. There was no significant loss of ketamine over 28 days at +20°C and over 7 days at +33°C. No degradation product was found during the study. This study indicates that ketamine solutions in the PCA systems are stable for a minimum of 28 days at room temperature.

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John Robert

Editorial Assistant

Research & Reviews: Journal of Hospital and Clinical Pharmacy

Email: clinpharmacy@journaloa.org